脑梗死患者血清同型半胱氨酸和高敏C反应蛋白水平分析

Analysis of serum homocystein and high sensitivity C-reactive protein levels in patients with cerebral infarction

目的：观察脑梗死患者血清同型半胱氨酸（Hcy）和高敏C反应蛋白（hs-CRP）水平的变化，探讨两者与脑梗死严重程度的关系。方法：测定74例脑梗死患者和70例健康对照者的血清Hcy、hs-CRP含量，并分析其与脑梗死患者临床神经功能缺损程度评分的相关性。结果：脑梗死患者血清Hcy、hs-CRP水平明显高于健康对照组（P〈0．01）。脑梗死不同临床分型组间血清Hcy、hs-CRP水平两两比较，Hcy差异无统计学意义（P〉0．05），hs-CRP差异有统计学意义（P〈0．01）。脑梗死患者血清hs-CRP含量与临床神经功能缺损程度评分呈显著正相关（r=0．631，P〈0．05）。结论血清Hcy、hs-CRP水平增高与脑梗死的发生有密切关系，hs-CRP能反映脑梗死的病变程度。

Objective To observe the regularity of fluctuation of serum homocysteine （Hcy） and high sensitivity C-reactive protein（hs-CRP） levels in patients with cerebral infarction and to investigate the relationships between the levels of hs-CRP, Hcy and pathogenetic condition of cerebral infarction. Methods The serum levels of Hcy and hs-CRP were measured in 74 patients with cerebral in- farction and 70 healthy controls, and the correlation with the scale of clinical neurologic deficit were analyzed. Results The levels of serum Hcy and hs-CRP in patients with cerebral infarction were sig~ nificantly higher than that in healthy controls （P〈0.01）. There was no significant difference of serum Hcy level among different clinical subtype groups of cerebral infarction （P〉0.05）, but the hs-CRP had a significant difference （P〈0.01）. There was a significant close positive correction between the level of hs-CRP and the scale of clinical neurologic deficit in patients with cerebral infarction （r =0. 631,P〈0.05）. Conclusion The high levels of serum Hcy and hs-CRP are highly associated with the occurence of cerebral infarction, and the level of hs-CRP may reflect the degree of cerebral infarction.