野木瓜酚性成分研究

Phenolic constituents from Stauntonia chinensis DC.

目的研究野木瓜（Stauntonia chinensis DC．）的化学成分。方法利用硅胶、SephadeXLH-20、ODS柱色谱及制备型HPLC等方法进行分离纯化，通过化合物的理化性质、波谱分析及化学反应鉴定其化学结构。结果与结论分离得到5个酚性成分，结构分别鉴定为：苏式-1-（4-羟基-3-甲氧基苯基）-1，2，3-丙三醇（1）、赤式-1-（4-羟基-3，5-二甲氧基苯基）-1，2，3-丙三醇（2）、4-羟基-2-甲氧基苯基-β-D-葡萄糖苷（3）、4-羟基-2-6-二甲氧基苯基-β-D-葡萄糖苷（4）、2-（4-羟基苯基）-乙基-（6-O-咖啡酰基）-β-D-葡萄糖苷（5）。化合物1～5均为从该属植物首次分离。

Aim To study the chemical constituents of Stauntonia chinensis DC. Methods The compounds were isolated by means of chromatography on silica gel, ODS column, Sephadex LH-20 column, and preparative HPLC. Their structures were elucidated by spectroscopic analysis and chemical methods. Results and conclusion Five phenolic compounds were obtained and identified as： threo-l-（ 4-hydroxy-3- methoxyphenyl）-1, 2, 3-propanetriol （1）, erythro-1-（4-hydroxy-3, 5-dimethoxyphenyl）-1, 2, 3-propanetriol （2）, 4-hydroxy-2-methoxyphenyl-β-D-glucopyranoside （3）, 4-hydroxy-2, 6-dimethoxyphenyl-β-D-glucopy- ranoside（4 ）, and 2- （ 4-hydroxyphenyl ） -ethyl- （ 6- O -caffeoyl ） -β-D-glucopyranoside （ 5 ）. Compounds 1, 2, 3, 4, and 5 were obtained for the first time from this genus.