N-取代四氮杂大环镧(Ⅲ)配合物的合成及其生物活性

Synthesis and biological activity of N-substituted tetraazamacrocycle Lanthanum(Ⅲ) complex

合成了2,2,4,9,9,11-六甲基-N1、N3-二乙酸四氮杂十四烷大环(A)和2,2,4,9,9,11-六甲基-N1、N3-二对甲基苯磺酰基四氮杂十四烷大环(B)以及它们的镧配合物,用元素分析、摩尔电导、IR和1H-NMR谱等手段表征了这些化合物的结构。初步生物活性表明,各化合物均有较强的抗肿瘤活性。

The synthesis of a new N-substituted tetraazamacrocycle（2, 2, 4, 9, 9, 11-hexamethyl-1,5, 8, 12- tetraazacyclotetradecan-N^1, N^3-diaceticacid（A） and 2, 2, 4, 9, 9, 11-hexamethyl-N^1, N^3-ditosyl-1,5, 8, 12- tetraazacyclotetradecan（B）, and their Lanthanum（ Ⅲ ） complex were reported. The compounds were characterized by elemental analysis, molar conductivity, measurement, IR and ^1H-NMR spectra. The preliminary biological activity studies show that the target compounds have strong antitumor activities.