从天然产物中寻找蛋白激酶C抑制剂的研究进展

Progress on protein kinase C inhibitors from natural products

蛋白激酶C(PKC)抑制剂对抗肿瘤、抗病毒、治疗心血管疾病等多种药物的合理设计有着非常重要的意义。该文对文献报道的天然产物中的PKC抑制剂依据化学结构进行分类,并对其生物来源、生物活性和作用位点进行综述。

PKC inhibitors play an important role in the rational design of new drugs, especially, antitumor agent, antivirus, cardiovascular drugs, etc. Many PKC inhibitors came from natural products. This article summarize the inhibitors which based on their chemical structures, origins, activities and action sites.