摘要
在过去的十年中,微卫星已经变成最流行的基因标记之一。尽管微卫星分析已有广泛的应用,然而关于微卫星DNA变异动力学的完整的画面才刚刚浮现。文章将从微卫星的起源、微卫星进化模式的推断、DNA复制的滑动是微卫星DNA变异的主要机制、影响微卫星突变率的因素、微卫星的长度分布和微卫星的频率分布等方面综述有关微卫星进化动力学方面的研究进展。
Within the past decade microsatellites have developed into one of the most popular genetic markers, Despite the widespread use of microsatellite analysis, an integral picture of the mutational dynanmics of microsatellite DNA is just beginning to emerge. This paper reviews the newest advance of evolutionary dynamics of microsatellite DNA from the following aspects ： Microsatellitc genesis, Inferring patterns of microsatellite evolution, DNA replication slippage is the predominant mutation mechanism of microsatellite DNA, Factors influencing microsatellite mutation rates, Length distribution of microsatellites, Frequency distribution of microsatellites and so on
出处
《激光生物学报》
CAS
CSCD
2007年第4期512-515,共4页
Acta Laser Biology Sinica
基金
山东省教育厅基金资助项目(J04C11)
聊城大学科技发展规划基金项目(X051005)
关键词
微卫星
重复
变异
microsatellite
repeat
mutation
