取代-3-甲酰基色酮与麦氏酸的固相缩合反应

Solid State Condensation of Substituted-3-Formylchromone and Meldrum's Acid

在无溶剂无催化剂条件下,采用石蜡油加热的方法,由取代-3-甲酰基色酮与麦氏酸通过Knoeve-nagel缩合反应合成了一系列5-（色酮基-3-亚甲基）麦氏酸类化合物,收率70%-87%,产物结构经IR,1H NMR确认.

5-（chromon--3- ylmethylidene）meldrum＇s acid are synthesized by Knoevenagel condensation of substituted-- 3--formylchromone and Meldrum＇s acid under the solid state condition of heating without organic solvent and catalyst, the yield was 70%-87% ,the products were indentified by ^1H NMR and IR.