慢性心力衰竭患者血清基质金属蛋白酶的变化及其临床意义

Changes and clinical significance of serum matrix metalloproteinase in patients with chronic cardiac failure

目的探讨慢性心力衰竭(CCF)患者血清基质金属蛋白酶-2、9(MMP-2、MMP-9)的变化及其临床意义。方法测定60例 CCF 患者及50名正常对照者 MMP-2、MMP-9水平,用超声心动仪测定两组患者心脏结构和功能指标,分析血清 MMP-2、MMP-9与 CCF 的关系。结果 CCF 患者血清 MMP-2、MMP-9水平明显高于对照者(P<0.05);左室收缩末内径、左室舒张末内径、左室收缩末期容积和舒张末期容积随着 CCF病情加重而增大(P<0.05),左心室射血分数随着 CCF 病情加重而降低(P<0.05)。结论 MMP-2、MMP-9共同参与了 CCF 的发生、发展,可作为反映心室重塑和心功能恶化的有效指标。

Objective To investigate the changes and clinical significance of serum matrix metalloproteinase-2,9（MMP-2, MMP-9） concentration in patients with chronic cardiac failure（CCF）. Methods Goncentrations of serum MMP-2, MMP-9 in patients with CCF（n = 60） and in normal controls（ n = 50） were measured. Gonstructive and functional parameters of heart were measured by echocardiography in all patients. The relationship between concentrations of serum MMP-2, MMP-9 and CCF was analyzed. Results Concentrations of serum MMP-2, MMP-9 in CHF were significantly higher than those in normal controls （P 〈 0.05 ）, left ventricular end systolic diameter （LVESD） and left ventricular end diastolic diameter （LVEDD）, left ventricular end systolic volume（LVESV） and left ventricular end diastolic volume（LVEDV） were enlarged with the aggravation of CCF（P〈 0.05）. But left ventricular ejection fraction（LVEF） was reduced with the aggravation of CCF（P 〈 0.05）. Conclusion Serum MMP-2, MMP-9 may be involved in occurrence and development of CCF and may be regarded as valid index of reflecting ventricular remodeling and depravation of heart function.