急诊PTCA联合脂微球载体前列腺素E_1治疗青年(≤45岁)急性心肌梗死的疗效研究

Clinical observations of emergent PTCA combined with Lipo-PGE_1 for the young patients with acute myocardial infarction

目的观察急诊 PTCA 联合脂微球载体前列腺素 E_1(Lipo-PGE_1)治疗青年(≤45岁)急性心肌梗死的临床疗效。方法对39例发病时间12 h 以内,45岁及以下急性心肌梗死患者行急诊 PTCA(必要时冠脉内植入支架),其中联合应用脂微球载体前列腺素 E_1者18例,观察疗效并进行统计分析、对照。结果39例患者中,梗塞相关血管再通37例(其中23例行支架置入)成功率94.9%。18例联合应用 Lipo-PGE_1的患者梗塞相关血管再通17例,成功率94.4%,术后半小时心电图 ST 段下降较未联合应用组明显,24 h 心功能改善较著,未出现血压、心率等的不良改变。结论急诊 PTCA 联合脂微球载体前列腺素 E_1治疗青年(≤45岁)急性心肌梗死治愈率高,能更好地消除梗塞后心绞痛和保护患者心功能。

Objective To evaluate the clinical effect in the treatment of the young patients（≤45 years old） with acute myocardial infarction（AMI） underwent emergent percutaneous transluminal coronary angioplasty（PTCA） combined with Lipo-PGE1. Methods 39 patients wkh AMI（paroxysm wkhin 12 hours） ,were underwent emergent PTCA（coronary stent performed in some patients） ,including 18 cases which were created combined with Lipo-PGE1 in the mean time. And the clinical efficacy and the results of short-period follow-up were recorded. Results The infarctive vasculars were re-open in 37 patients（23 cares were routinely placed translunxinal stents）, and the successful rate was 94.9 %. Those who also used Lipo-PGEI were re-open in 17 patients. The successful rate was 94.4 %, their ST segments on EKG 30 minutes after operations reduced significan＇dy than that of patients who did not use LipoPGE1 ,their cardial functions were also improved significantly 24 hours after operations and no side effects on blood pressure and heart rate were observed. Conclusion The emergent PTCA combined with Lipo-PGE1 for acute myocardial infarction can protect the cardial function and show a better early therapy effect.