左氧氟沙星与加替沙星治疗社区获得性肺炎的成本-效果分析

Analysis of the cost-effect in curing community-acquired pneumonia with levufloxacin and gatifioxacin

目的比较左氧氟沙星与加替沙星治疗社区获得性肺炎的成本-效果,为临床合理用药提供参考。方法选择社区获得性肺炎97例,分为左氧氟沙星组(左氧组)与加替沙星组(加替组),统一观察疗效、检查和收费项目,分别给予左氧氟沙星和加替沙星治疗7～10 d,观察治疗效果并进行成本-效果分析。结果左氧组总有效率91.1%,不良反应发生率11.1%,平均成本1096元,C/E 值=12.0,加替组总有效率93.9%,不良反应发生率8.2%,平均成本1302元,C/E 值=14.1,成本-效果分析ΔC/ΔE=80元,两组总有效率比较,差异无统计学意义(P>0.05)。结论左氧氟沙星治疗社区获得性肺炎比加替沙星更具有药物经济学优势,应优先选择。

Objective Compare levofloxacin with gatifloxacin for curing the cost-effect of community-acquired pneumonia,provide a reference for clinical reasonable use a medicine. Methods Choosed the community-acquired pneumonia 97 cases and were divided into levofloxacin group with gatifloxacin group,observed curative effect, check and charge item, gived respectively levofloxacin and gatifloxacin to cure 7-10 days,observed treatment effect and carried on cost-effect analysis. Results Levofloxacin group efficient was 91. 1% ;incidence rate of adverse reaction was 11.1% , average the cost was 1096 dollars,C/E value= 12.0, gatifloxacin group efficient was 93.9 % ,incidence rate of adverse reaction was 8.2 %, average the cost was 1302 dollars, C/E value = 14.1, cost-effect analysis was ΔC/ΔE = 80 dollars, two groups of efficient compared was not significant differences（ P 〉 0.05 ）. Conclusion Levofloxacin treating community-acquired pneumonia than gatifloxacin have more medicine economics advantage and it is in the prior choice.