生脉成骨片对早期股骨头坏死塌陷的影响

Effect of Shengmai Chenggu Tablets for Collapse of Early Necrotic Femoral Head

目的:观察生脉成骨片口服结合负重控制对早期股骨头坏死塌陷的影响。方法:对早期股骨头坏死未采取治疗措施的患者,按年龄、性别、坏死病因、分期和范围组间匹配后,设为2组。中药组43例44髋,采取控制髋关节负重、口服生脉成骨片等措施治疗;自然病程组(自然组)38例48髋无系统治疗。平均随访4年,进行组间影像学进展和股骨头塌陷>2mm为终点的Kaplan-Meier生存率比较分析。结果:影像学进展:中药组9髋(20.5%),自然组23髋(47.9%),2组比较,差异有非常显著性意义(P<0.01);股骨头塌陷>2mm:中药组5髋(11.4%),自然组21髋(43.8%),2组比较,差异有非常显著性意义(P<0.01);Kaplan- Meier生存率分析,中药组股骨头塌陷明显比自然组低(P<0.01)。结论:生脉成骨片治疗结合负重控制对早期股骨头坏死具有抑制影像学进展、阻止股骨头塌陷的作用。

Objective:To observe the effect of oral use of Shengmai Chenggu Tablets(SCT,生脉成骨片)and weight-burden control on collapse of early necrotic femoral head.Mothods:Patients with early necrotic femoral head were divided into two groups according to their age,sex and the pathogens,stage and size of necrosis.Group A(including 44 affected hips in 43 patients)received weight-burden control and oral use of SCT,group B(including 48 affected hips in 38 patients)did not receive sys- temic treatment.The average follow-up time was 4 years.With imaging features and femoral head collapse over 2mm as the parameters,Kaplan-Meier survival rate was analyzed in the two groups.Results:Imaging features developed in 9(20.5%)of group A and in 23(47.9%)of group B,the difference being significant(P<0.01). Femoral head collapse over 2mm was found in 5(11.4%)of group A and in 21 (43.8%)of group B(P<0.01).The result of Kaplan-Meier survival rate analysis showed that the incidence of femoral head collapse was lower in group A than that in group B(P<0.01).Conclusion:Oral use of SCT combined with weight-burden control has a preventive effect on collapse of early necrotic femoral head.