依帕司他在治疗糖尿病多神经病变中的疗效

Clinical Efficacy of Epalrestat for Diabetic Distal Symmetric Polyneuropathy

目的:通过观察依帕司他对糖尿病多神经病变症状、神经传导潜伏期的改善,来探讨本药的疗效。方法:按照随机、单盲、安慰剂对照原则,54例糖尿病多神经病变患者被随机分为依帕司他治疗组(30例)及安慰剂对照组(24例),分别记录治疗前后主观症状及神经传导潜伏期的变化情况。结果:治疗8周后治疗组患者症状、神经传导潜伏期与对照组相比差异有统计学意义。结论:依帕司他对糖尿病多神经病变疗效肯定。

Objective：The purpose of this study was to evaluate the efficacy of epalrestat in a placebo controlled study in patients with type 2 diabetes and associated distal symmetric polyneuropathy. Methods： A total of 54 patients with diabetic neuropathy were treated with placebo or epalrestat. The efficacy evaluation was based on change in electrophysicological measurements of sensor latent period, as well as an assessment of subjective symptoms. Results： The epalrestat - treated group was significantly improved compared with the placebo group in electrophysicological measurements. Subjective symptoms also significantly benefited from epalrestat group versus placebo group. Conclusions： The effects of epalrestat - treatment on nerve latent period and the subjective symptoms of diabetic neuropathy provide evidence that this drug alters the progression of diabetic neuropathy.