核因子-κB参与阻塞性睡眠呼吸暂停低通气综合征的机制研究

Research on mechanism of nuclear factor-κB in obstructive sleep apnea hypopnea syndrome

转录因子NF-κB是OSAHS发病机制中的重要环节，活化后广泛调控黏附分子和炎症相关的酶及蛋白质的表达，参与OSAHS心血管及呼吸系统疾病等并发症发生发展，抑制NF—κB的活化将明显减少OSAHS心血管事件等并发症的发生率。

Transcription factor nuclear factor-kappa B is important in the pathogenesis of OSASHS. It regulates adhesion molecular and the expressions of the enzymes and the proteins that are related with inflammation ,participate in the development of the cardiovascular and respiratory complications of OSAHS, once it is activated. When the activation is inhibited,the incidence of complications is reduced significantly.