尼美舒利对胃溃疡模型大鼠的保护作用研究

Protective Effect of Nimesulide on Experimental Gastric Ulcer in Rats

目的:研究环氧化酶-2选择性抑制剂尼美舒利对药物诱导胃溃疡的保护作用。方法:采用吲哚美辛灌胃给药制备大鼠胃溃疡模型,5min后按组别给予高、中、低(200、100、50mg·kg-1)不同剂量尼美舒利,6h后处死大鼠,观察胃溃疡面积和胃黏膜的损伤程度,检测血清及胃黏膜中超氧化物歧化酶(SOD)、丙二醛(MDA)和谷胱甘肽(GSH)值的变化。结果:与模型组比较,尼美舒利组大鼠胃溃疡面积明显减小,MDA水平降低,SOD和GSH活性升高(P<0.05或P<0.01)。结论:尼美舒利对吲哚美辛所致大鼠胃溃疡具有明显的保护作用。

OBJECTIVE： To study the protective effects of nimesulide, a COX - 2 selective inhibitor on experimental gastric ulcer in rats. METHODS： The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages （200, 100, and 50mg · kg ^-1）, 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS： As compared with model group, in nimesulide （at different dosage） groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased （P〈0.05 or P〈0.01） . CONCLUSION ： Nimesulide has a good protective effect on indometacininduced gastric ulcer in rats.