职业性慢性苯中毒的发生与ABO血型分布关系的探讨

Relationship between blood type distribution and occupational chronic benzene poisoning

目的初步探讨苯接触人群慢性苯中毒的发生与ABO血型分布关系。方法以某职业病防治院确诊的95例苯中毒病人作为病例组,以日常健康监护中白细胞计数偏低（WBC〈4.0×10^9/L）的苯接触者98例作为疑似病例组。分析其ABO血型的分布情况,并与对照组（上海生物制品研究所血型组调查ABO血型分布的40 980名汉族人）进行比较。结果病例组A、B、O和AB型的分布频率分别为24.2%、29.5%、42.1%和4.2%;疑似病例组分别为26.5%、21.4%、43.9%和8.2%;对照组分别为31.3%、28.1%、30.9%和9.8%。病例组与普通人群组ABO血型分布不一致（Х^2=8.474,P〈0.05）,O型/非O型OR为1.629（95%CI为1.084-2.450,P〈0.05）;疑似病例组与普通人群组ABO血型分布同样不一致（Х^2=10.608,P〈0.05）,O型/非O型OR为1.752（95%CI为1.175-2.612,P〈0.01）。结论O型血可能是慢性苯中毒的危险因素。

Objective To study association between blood type distribution and chronic benzene poisoning among workers exposed to benzene. Methods 95 benzene poisoning patients diagnosed in a occupational disease hospital and 98 exposed persons （ WBC 〈4. 0×10^9/L） found in regular health examination were selected as case and suspect group. Which were analyzed the blood type distribution compared to control group of 40 980 common Han people from a blood type survey conducted by Shanghai Biological Products Research Institute. Results The distribution of A,B,O and AB blood type were 24. 2% ,29.5%, 42. 1% and 4.2% in case group,26. 5% ,21.4% ,43.9% and 8.2% in suspect group, 31.3% ,28.1%, 30.9% and 9. 8% in control group respectively. The blood type distribution of case group were observed significant difference with control group （ Х^2 = 8.474, P 〈 0. 05 ） and OR of O to non-O type equaled to 1. 629 （95% CI：1. 084 -2. 450,P 〈0. 05 ）, as well as suspect group（z2 = 10. 608,P 〈0. 05） with OR = 1. 752 （95% CI： 1. 175 -2. 612,P 〈0.01）. Conclusion O blood type may be one of the risk factors associated with chronic benzene poisoning.