阿魏酸钠联合羟氯喹治疗老年类风湿关节炎的临床观察

Clinical Treatment of Elderly Rheumatoid Arthritis with Sodium Ferulate and Hydroxychloroquine

目的探讨阿魏酸钠(SF)治疗老年类风湿关节炎(EORA)的疗效和安全性。方法将52例EORA患者随机分为羟氯喹(HCQ)治疗组(对照组,24例,口服塞来昔布200mg/次,2次/d;HCQ200mg/d),阿魏酸钠(SF)联合HCQ治疗组(治疗组,28例,在对照组治疗基础上加用SF300mg入0.9%氯化钠溶液250ml静滴,1次/d),两组均4周为一疗程。于治疗前后分别测定关节疼痛指数、关节肿胀指数、晨僵时间、双手平均握力、20m步行时间、红细胞沉降率(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)、免疫球蛋白(Ig)、血尿常规、血清丙氨酸氨基转移酶(ALT)、血清天门冬氨酸氨基转移酶(AST)、血清碱性磷酸酶(ALP)、血清肌酐(Cr)、血清尿素氮(BUN)、血清尿酸(UA)等指标,治疗前后检查心电图、眼科情况,记录不良反应。结果两组患者疗效间差别有显著性意义(P<0.05),治疗组患者治疗后关节疼痛指数、关节肿胀指数、晨僵时间、双手平均握力、20m步行时间、ESR、CRP、RF、Ig等指标与对照组间差别均有显著性意义(P<0.05)。两组不良反应发生率间差别无显著性意义(P>0.05)。结论SF联合HCQ治疗EORA疗效较好。

Objective To study the therapeutic efficacy and safety of Sodium Ferulate （SF） in treating elderly onset rheumatoid arthritis （EORA）. Methods Totally 52 EORA eases were randomly divided into 2 groups： the control group treated with eeleeoxib 200mg, two times a day, and Hydroxyehloroquine （HCQ） 200mg/d; and the trial group treated with intravenous dripping of SF 300mg/d in 250 ml of 0. 9% saline additionally besides the therapy for the control group, the therapeutic course for both groups was 4 weeks. Before and after treatment, the indexes of joint tenderness, swelling and morning stiffness ; the average power of gripping of both hands, the time for 20 m walking, erythrocyte sedimentation rate （ ESR）, C - reactive （ CRP）, rheumatoid factor （RF） , immunoglobulin （Ig） , routine blood and urine examinations, alanine amiotransferase （ALT）, asparrate aminotransferase （AST）, serum alkaline phosphatase （ALP） , serum ereatinine （SCr） , blood urea nitrogen （BUN） , and uric acid （UA） were detected; and the electrocardiogram （EKG）, ophthalmic conditions and untoward effects were recorded too. Results There was a significant difference in effects between the two groups （ P 〈 0. 05 ）. After treatment, there were significant differences in the indexes of joint tenderness, swelling and morning stiffness; the average power of gripping of both hands, the time for 20 m walking, ESR, CRP, RF and Ig （ P 〈 0.05）. And there was no significant difference in untoward effects between the two groups （ P 〉 0. 05 ）. Conclusion The therapy of SF and HCQ is of better effect in treating EORA.