血必净注射液对脓毒症患者应激反应的影响

The Effect of Xuebijing Injection on Stress Reaction in Patients with Sepsis

目的探讨血必净对脓毒症患者应激指标C-反应蛋白(CRP)、血小板(PLT)的影响。方法将确诊为脓毒症的35例患者随机分成两组,对照组(n=15)患者给予抗生素、对症及常规营养支持治疗,如病情需要可给予脏器替代治疗,包括使用呼吸机和/或血液透析;血必净组(n=15)患者在对照组治疗的基础上加用血必净注射液100ml,静脉滴注,1次/12h,连用7d,对患者进行CRP、PLT测定,同时观察患者WBC的变化。结果治疗前后,血必净组C-反应蛋白、PLT水平间差别有显著性意义(P<0.05),治疗后与对照组间差别有显著性意义(P<0.05);治疗前后血必净组WBC数间差别有显著性意义(P<0.05),治疗后血必净组与对照组间差别无统计学意义。结论加用血必净注射液可显著降低脓毒症患者的应激反应。

Objective To investigate the effect of Xuebijing injection on stress reaction in patients with sepsis. Methods 35 patients with sepsis were randomly divided into control group （n = 15 ） and Xuebijing group （n = 20）, The control group was given traditional western treatment, while the Xuebijing group received Xuebijing injection （ 100 ml, per 12 h, 7 d） in addition besides traditional western medicine treatment. The CRP, PLT, WBC of the patients were measured. Results The CRP of Xuebijing group after treatment was significantly different from that before treatment （ P 〈 0.05 ）, and there was significant differnee （ P 〈 0.05） between Xuebijing group and control group after treatment; the WBC of Xuebijing group after treatment was significantly different from that of post - treatment （ P 〈 0.05 ）, and there was no significant difference in WBC between Xuebijing group and control group after treatment, Conclusion Xuebijing injection can effectively decrease stress reaction in patients with sepsis.