阿立哌唑治疗首发精神分裂症的临床观察

The Effect of Aripiprazole on First-onset Schizophrenia

目的了解阿立哌唑对首发精神分裂症患者的疗效与耐受性。方法用阿立哌唑治疗56例首发精神分裂症(包括分裂样精神障碍)患者6周,采用阳性与阴性症状量表(PANSS)、副反应量表(TESS)评定疗效及不良反应。结果56例患者治疗后,临床显效率为82.14%,有效率达94.64%,治疗前后患者的PANSS减分率间差别有显著性意义(P<0.01),不良反应主要有轻度的锥体外系症状(EPS)、头痛、失眠、焦虑等,患者的血糖、血脂、体重治疗前后间差别均无显著性意义(P>0.05)。结论阿立哌唑治疗首发精神分裂症患者疗效肯定,不良反应少,依从性较好。

Objective To investigate the effect and side effects of aripiprazole on first - onset schizophrenia. Methods 56 patients with first - onset schizophrenia were treated with arripiprazole for 6 weeks, to evaluate its effect by PANSS and TESS. Results After six - week treatment, the rate of clinical effect was 82 14%, and the effective rate was 94 64%. Significant difference was found in rate of reduction between pre - treatment and post - treatment （ P 〈 0. 01 ）, and untoward effects were mainly mild EPS, headache, insomnia and anxiety etc. There was no significant difference in blood gluoose, lipid, body weight and laboratory indexes between pre - treatment and post - treatment. Conclusion The results confirm the effect of arripiprazole on patients with first -onset schizophrenia, with little untoward effects and good obedience.