骨源性碱性磷酸酶检测在婴幼儿营养性佝偻病诊治中的应用

Application of the Detection of Bone Alkaline Phosphatase in the Diagnosis and Treatment of Infant Nutritive Rickets

目的评价骨源性碱性磷酸酶(BALP)在婴幼儿营养性佝偻病早期诊断及治疗中的应用价值。方法①对1517例婴幼儿应用BALP试剂盒进行检测。②对部分BALP检测结果异常者进行治疗后复查,观察BALP值的变化。结果BALP>200U/L检出率为73.5%;以BALP≥250U/L为临床诊断界限值,异常检出率为35.4%。134例用维生素D制剂治疗后复查,有效率为79.9%。结论BALP检测对婴幼儿营养性佝偻病诊治有重要的临床价值。

[ Objective] To evaluate the application value of bone alkaline phosphatase detection in the early diagnosis and treatment of infant/children nutritive rickets. [ Methods] BALP reagent box was used to detect 1517 infants and children; recheck was made on the infants and children who were found with abnormal result in the BALP detection ; BALP vale was observed. [ Results] The detection rate （ BALP 〉200 U/L） was 73.5% ; the abnormal detection rate was 35.4% with BALP 〉250 U/L as the clinical diagnosis limit; the effective rate of vitamin D intake was 79.9% among the 134 cases. [ Conclusion] BALP detection has important clinical value in the diagnosis and treatment of infant/children nutritive rickets.