不同次数支气管肺泡灌洗对胎粪吸入综合征的效果评价

Effects of different frequency bronchoalveolar lavage on meconium aspiration syndrome

目的探讨不同次数支气管肺泡灌洗对新生儿胎粪吸入综合征预后的影响。方法将62例新生儿胎粪吸入综合征患儿随机分为A、B、C三组:A组22例,灌洗≤2次;B组20例,灌洗>2次;C组20例,未灌洗。比较三组气漏、缺氧缺血性脑病、呼吸暂停、心跳减慢发生率、机械通气时间、住院天数及死亡率。结果A组气漏、缺氧缺血性脑病、呼吸暂停、心跳减慢发生率、机械通气时间、住院天数及死亡均显著低于B、C两组,差异均有显著或极显著性(P<0.05或0.01)。B、C两组各项指标比较均无显著性差异(P均>0.05)。结论对新生儿胎粪吸入综合征支气管肺泡灌洗≤2次,可减少并发症,缩短机械通气时间和住院天数,降低病死率。

Objective To explore the effects of different frequency bronchial layage on prognosis of newborn rneeoniurn aspiration syndrome（MAS）. Methods 62 MAS newborn were randomly divided into group A（n=22）,B（n=20） and C（n=20）, group A lavages ≤2, group B did 〉2 and group C didn＇t. Comparisons of frequent hemorrhoid, hypoxie-ischemie eneephalopathy（HIE）, apnea, incidence of bradyeardia, mechanical ventilation duration, hospital days and mortality were conducted among the 3 groups. Results Above indices were significantly lower in group A than in B and C, differences significant or very（P〈0. 05 or 0.01）. There was no significant difference in all indices between group B and C（P〉0.05）. Conclusion Bronchial lavage less than or equal to 2 times can lessen complications, shorten mechanical ventilation duration and hospital days and lower ease fatalitv.