季德胜蛇药加呋喃西林湿敷治疗阿霉素外渗致兔局部组织损伤的效果观察

Effect of Different Therapies in the Treatment of Rabbit Local Tissue Injury Induced by Adriamycin Effusion

目的探讨阿霉素外渗致组织损伤的理想治疗方法。方法选择体质量2.5～3.0 kg的健康雌性新西兰成年兔6只,用阿霉素注入兔两后腿血管周围,建立阿霉素外渗的兔损伤模型。6只兔分为3组,每组2只,3组分别采用1∶5000呋喃西林加季德胜蛇药外敷,复方利多卡因局部封闭和50%硫酸镁湿敷治疗,观察3组治疗后的肿胀消退指数和光学显微镜下组织学改变。结果1∶5000呋喃西林加季德胜蛇药外敷治疗组,肿胀消退指数(0.226±0.030)cm2/h,治疗第7天显微镜下见大量肉芽组织,痊愈;复方利多卡因治疗组肿胀消退指数(0.087±0.034)cm2/h,治疗第7天显微镜下见少量肉芽组织生长;50%硫酸镁湿敷治疗组肿胀消退指数(0.051±0.013)cm2/h,治疗第7天显微镜下见大量坏死组织和菌落。结论1∶5000呋喃西林加季德胜蛇药外敷治疗阿霉素外渗所致局部组织损伤疗效最佳,复方利多卡因治疗组和50%硫酸镁湿敷组疗效甚微,1∶5000呋喃西林加季德胜蛇药外敷治疗阿霉素外渗是一种行之有效的处理方法。

Objective To explore the ideal method to treat tissue injury caused by Adriamycin effusion. Methods 6 New Zealand adult female rabbits weighted 2.5-0.3 kg were randomized into 3 groups equally. Rabbit tissue injury model by Adriamycin effusion was established by injecting Adriamycin into 2 hinder legs of rabbits. First group included 2 rabbits were treated by 1：5 000 furacilin plus Jidesheng Snake Plaster, the second by local sealing with Lidocaine and the third by 50% MgSO4. The index of tumefaction and histopathological changes under optical microscope among the three treatment groups were observed and compared. Results The indexes of tumefaction were （0.226±0.030）cm^2/h, （0.087±0.034）cm^2/h and （0.051±0.013）cm^2/h in the first, the second and third group, respectively. On day 7, large quantities of granulation tissues were seen in the first group under microscope, a few in the second group and necrotic tissues and bacterium colony in the third group. Conclusion The therapy of 1：5 000 furacilin plus Jidesheng Snake Plaster is the most effective in treating rabbit local tissue injury induced by Adriamycin effusion. Lidocaine and MgSO4 are less effective.