不同乳化剂制备阿司匹林微球工艺的研究

Preparation of polylactic acid enveloped aspirin microspheres

目的以聚乳酸为载体用溶剂挥发法制得阿司匹林聚乳酸微球。方法选择不同的乳化剂,正交设计实验。以微球包埋率、载药量、表面形态、体外释放为指标优化微球的制备工艺。结果与结论按优化条件制得的微球粒径5～22μm,占80%以上。微球包埋率39.5%,载药量7.25%,体外释药50%需70h。

Objective Polylactic acid enveloped aspirin microspheres were prepared by solvent evaporation method. Method The orthogonal test of 3 factors and 3 levels was applied to optimize the preparation procedure. The particle appearance, drug content, and rate of encapsulation were used to evaluate the preparation procedure. Results and Conclusion Microspheres in the range of 5~ 22 μm were obtained. The drug content was 7.25% and encapsulated rate was 39.5% ,and t1/2 （in vitro） was 70 h. The results showed the microspheres prepared dy the method had obviously release effect.