血必净注射液用于机械通气患者疗效观察

Clinical observation of Xuebijing injection(血必净注射液)on 40 patients with mechanical ventilation

目的:评价血必净注射液对机械通气患者的治疗效果。方法:将40例机械通气患者按随机原则分为对照组和治疗组,每组20例。对照组给予机械通气、抗生素、对症及营养支持治疗;治疗组在对照组治疗的基础上加用血必净注射液50ml静脉滴注,12h1次,连用7d。比较两组患者治疗前和治疗后5d的血白细胞计数(WBC)、C-反应蛋白(CRP)、气道压力、动脉血气以及成功撤机率、重症加强治疗病房(ICU)病死率。结果:两组患者的年龄和急性生理学与慢性健康状况评分系统(APACHE)差异均无显著性(P均>0.05),有可比性。治疗前两组患者的气道压力、动脉血气、WBC、CRP比较差异均无显著性(P均>0.05);治疗后5d治疗组患者的气道压力、动脉血气、CRP改善程度均显著优于对照组(P均<0.05),撤机成功率显著高于对照组(80%比50%,P<0.05),ICU病死率显著低于对照组(20%比50%,P<0.05)。结论:血必净注射液有利于机械通气患者拔管撤机,能降低机械通气患者的ICU病死率。

Objective： To evaluate the therapeutic effects of Xuebijing injection （血必净注射液） on patients treated with mechanical ventilation （MV）. Methods： Forty patients treated with MV were randomly divided into a control group （n=20） and a treatment group （n= 20）. The two groups were all treated with MV, antibiotics, symptomatic and nutrition support treatment, and the only difference was that Xuebijing injection 50 ml was given every 12 hours for 7 days to the treatment group. The differences between two groups were evaluated in airway pressure, arterial blood gas, white blood cells （WBC）, C- reactive protein （CRP）, ventilator weaning and mortality in intensive care unit （ICU）. Results ： The age and acute physiology and chronic health evaluation n （APACHE n ） scores of the two groups had no significant differences （both P〉0.05）. The differences between two groups had no significance in airway pressure, arterial blood gas, WBC, CRP before treatment （all P〉0.05）. Airway pressure, arterial blood gas, CRP, ventilator weaning rate （80% vs. 50%） of the treatment group were all improved more significantly as compared to those of control group on the 5 th day after treatment （all P〈0.05）. The mortality in ICU was obviously decreased in the treatment group than that in the control group （20% vs. 50%, P〈0.05）. Conclusion： Xuebijing injection can favor ventilator weaning and lower the mortality of patients treated with MV in ICU.