期刊文献+

神经网络在药动学评价中的应用 被引量:1

下载PDF
导出
摘要 神经网络是一种数据分析方法,具有并行性、容错性、非线性和自学习性等特点。在化学、药学和生物学等领域中,正在逐步取代传统的线性方法而成为数据分析的主要方法。近几年来,在药动学评价的研究领域中,神经网络模型也得到了广泛应用。因为药动学涉及到非线性的过程,所以,神经网络模型在此领域的表现大大优于传统的线性模型。该文在总结有关文献的基础上概述了近年来神经网络在药剂评价、新药的药动学评价和药物的临床评价等几个方面的应用情况。
作者 戴康 王晓琼
出处 《医药导报》 CAS 2007年第9期1048-1049,共2页 Herald of Medicine
基金 国家自然科学基金资助项目(基金编号:20307004)
  • 相关文献

参考文献10

  • 1SOLOMATINE D P,SIEK M B.Modular learning models in forecasting natural phenomena[J].Neural Netw,2006,19(2):215 -224.
  • 2PAPADOKONSTANTAKIS S,LYGEROS A,JACBSSON S P.Modular learning models in forecasting natural phenomena[J].Neural Netw,2006,19(4):500 -513.
  • 3GOLLER A H,HENNEMANN M,KELDENICH J,et al.In silico prediction of buffer solubility based on quantum-mechanical and HQSAR-and topology-based descriptors[J].J Chem Inf Model,2006,46(2):648 -658.
  • 4WEI L,YANG Y,NISHIKAWA R M,et al.A study on several machine-learning methods for classification of malignant and benign clustered microcalcifications[J].IEEE Trans Med Imaging,2005,24(3):371 -380.
  • 5GAO J,WANG X,LI X,et al.Prediction of polyamide properties using quantum-chemical methods and BP artificial neural networks[J].J Mol Model,2006,12(4):513 -520.
  • 6GRAG P,VERMA J.In silico prediction of blood brain barrier permeability:an artificial neural network model[J].J Chem Inf Model,2006,46(1):289 -297.
  • 7WANG Y H,LI Y,LI Y H,et al.Modeling Km values using electrotopological state:substrates for cytochrome P450 3A4-mediated metabolism[J].Bioorg Med Chem Lett,2005,15 (18):4076 -4084.
  • 8王泽,李新城,朱伟兴.药物生物利用度遗传神经网络预测研究[J].药学学报,2006,41(12):1180-1183. 被引量:8
  • 9PAROJCIC J,IBRIC S,DJERIC Z,et al.An investigation into the usefulness of generalized regression neural network analysis in the development of level a in vitro-in vivo correlation[J].Eur J Pharm Sci,2007,30(3 -4):264 -273.
  • 10BELIC A,GRABNAR I,BELIC I,et al.Predicting the anti-hype-rtensive effect of nitrendipine from plasma concentration profiles using artificial neural networks[J].Gomput Biol Med,2005,35 (10):892 -904.

二级参考文献4

共引文献7

同被引文献9

  • 1KUNAL R,PARTHA P R.Comparative QSAR studies of CYP1A2 inhibitor flavonoids using 2D and 3D descriptors[J].Chem Biol Drug Des,2008,72(5):370-382.
  • 2DU Q S,HUANG R B,WEI Y T,et al.Fragment-based quantitative structure-activity relationship (FB-QSAR) for fragment-based drug design[J].J Comput Chem,2009,30(2):295-304.
  • 3YU A M.Indoleakylamines:biotransformations and poten-tial drug-drug interaction[J].AAPS J,2008,10(2):242-253.
  • 4NICULESCU S P.Artificial neural networks and genetic algorithms in QSAR[J].J Mole Stru Theochem,2003,122(22):71-83.
  • 5RAZZAQUE A,HEALD M A,PICKARD J D,et al.Vas-oconstriction in human isolated middle meningeal arteries:determining the contribution of 5-HT1B-receptor and 5-HT1F-receptor activation[J].Br J Clin Pharmacol,1999,47(1):75-82.
  • 6RAMADAN N M,SKLJAREVSKI V,PHEBUSL A.5-HT1F receptor agonists in acute migraine treatment:a hypothesis[J].Cephalalgia,2003,23(8):776-785.
  • 7KARAMJIT S J,VIKKI B,MICHAEL B,et al.Discover of 4-[3-(trans-3-Dimethylaminocyclobutyl) -1H-indole-5-ylmethyl]-(4S)-oxazolidin-2-one(4991W93),a 5-HT receptor partial agonists and a potent inhibitor of electrically induced plasma extravasation[J].J Med Chem,2001,44(5):681-693.
  • 8JOSE' L,CASTRO L J,STREET A R,et al.3-[2-(Pyrr-olidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)pro-pyl]indoles:agonists for the 5-HT receptor with high selectivity over the h5-HT Subtype[J].J Med Chem,1997,40,3497-3500.
  • 9WANG Y H,LI Y,LI Y H,et al.Modeling km values using electrotopological state:substrates for cytochrome P450 3A4-mediated metabolism[J].Bioorg Med Chem Lett,2005,15:4076-4084.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部