联合检测宫颈阴道分泌物FFN和IL-6对早产的预测价值

Significance of combined detection of cervicovaginal fetal fibronectin and interleukin-6 in predicting preterm delivery

目的了解先兆早产孕妇和正常妊娠孕妇的宫颈阴道分泌物中的胎儿纤维连接蛋白(FFN)、白细胞介素6(IL-6)的水平,观察联合检测FFN、IL-6是否提高预测早产的准确性。方法使用ELISA法测定43例妊娠28～36周并诊断为先兆早产的孕妇(研究组)和41例同期同孕龄的正常孕妇(对照组)的宫颈阴道分泌物FFN和IL-6。结果(1)研究组的FFN和IL-6的含量高于对照组(P<0.05),妊娠结局为早产组的FFN和IL-6的含量高于足月产组(P<0.05)。FFN和IL-6呈正相关性(r=0.657,P<0.05)。(2)FFN预测早产和1周内分娩的敏感度和阳性预测值高于IL-6,而特异度和阴性预测值则低于后者。结论(1)FFN和IL-6的浓度与早产相关,FFN和IL-6有正相关性。(2)FFN和IL-6均是预测早产和1周内分娩的较为敏感的指标,联合检测两项指标将提高预测早产和1周内分娩的预测能力。

Objective To evaluate the significance of detecting FFN and IL-6 in cervicovaginal secretions of women with threatened preterm labor in predicting preterm delivery. Methods Samples of cervicovaginal secretion were obtained from 43 patients with the diagnosis of threatened preterm labor （study group） and 41 pregnant women between the same gestational weeks（control group） ,and FFN and IL-6 were measured by ELISA. Results （1） FFN and IL-6 levels in study group were higher than those in control group（P〈0. 05）, which in the patients with preterm parturition were higher than those in the cases with term parturition（P〈0. 05）. FFN level was positively correlated with IL-6 level（r=0. 657,P〈0. 05）. （2） The sensitivity and the negative predictive value in predicting preterm delivery and delivery within one week were higher with FFN than those with IL-6, but the specificity and the positive predictive value predicted by IL-6 were lower. Conclusions （1） FFN and IL-6 concentrations had relationships with preterm delivery, and FFN level was positively correlated with IL-6 level. （2）FFN and IL-6, especially combined detection, were the sensitive markers for predicting preterm delivery and delivery within one week.