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子宫内膜癌L-选择素的表达 被引量：3

Expression of L-selectin in patients with carcinoma of endometrium
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摘要 目的探讨L-选择素(L-selectin)在子宫内膜癌中的表达。方法采用RT-PCR技术检测16例子宫内膜癌组织和16例正常子宫内膜组织中L-选择素的表达。结果癌组织、癌旁组织、正常子宫内膜均有L-选择素表达,L-选择素相对于内参照β-肌动蛋白的相对表达量,癌组织为1.03±0.11,癌旁组织为0.49±0.13,正常组织为0.51±0.15,癌组织显著高于癌旁组织和正常子宫内膜组织(P<0.01)。结论L-选择素在子宫内膜癌中高表达,可能与肿瘤的发生、发展和转移密切相关。 Objective To investigate the expressions and roles of L-selectin in patients with carcinoma of endometrium. Methods Reverse transcription polymerase chain reaction （RT-PCR） method was used to detect and quantify L-selectin mRNA expression levels in carcinoma tissue and para-carcinoma tissue of 16 patients with carcinoma of endometrium and the normal endometrium of 16 healthy women. Results The expression of L-selectin was observed in carcinoma tissue, paracarcinoma tissue and normal endometrium. The expression level in carcinoma tissue was significantly higher than that in para-carcinoma tissue of the patients with carcinoma of endometrium （1.03±0. 11 vs. 0. 49±0. 13,P〈0.01） ,and than that in normal endometrium （1.03±0.11 vs. 0. 51±0. 15,P〈 0. 01）. Conclusion The higher expression of L-selectin in the carcinoma tissue from the patients with carcinoma of endometrium may indicate a close relationship with production and metastasis of cancer cells.
作者 张国英 王淑玉
机构地区 南京医科大学第一附属医院妇产科
出处 《江苏医药》 CAS CSCD 北大核心 2007年第9期902-903,共2页 Jiangsu Medical Journal
关键词 L-选择素 子宫内膜癌 L-selectin Carcinoma of endometrium
分类号 R737 [医药卫生—肿瘤]
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参考文献6

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二级参考文献13

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共引文献23

同被引文献16

  • 1刘敏,王莉芬,朱杰,杨佩满,张嘉宁.L-选择蛋白可能介导小鼠肝癌HCa-F细胞经淋巴道转移的研究[J].解剖学报,2004,35(5):502-508. 被引量：18
  • 2瞿春莹,董国芳,汪余勤,陈梅梅,李定国.78例早期胃癌患者内镜及组织病理学分析[J].实用诊断与治疗杂志,2007,21(10):732-733. 被引量：20
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引证文献3

二级引证文献6

江苏医药
2007年 第9期

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