^(18) F-FDG SPECT显像诊断Alzheimer病

Diagnostic Value of ^(18)F-FDG SPECT Image in Early Alzheimer's Disease

目的:探讨^(18)F-脱氧葡萄糖(FDG)单光子发射型电子计算机断层(SPECT)显像诊断Alzheimer病(AD)的影像特点和诊断标准。方法:静脉注射^(18)F-FDG后行脑断层显像,获得颞、顶、额叶等显像特征并加以分析。结果:早期AD 15例,简易智能状态量表(mini-mental state examination,MMSE)评分21～26分,多表现单侧尤其是优势半球或者双侧对称性异常代谢灶。中晚期AD 32例,MMSE评分<21分,表现双侧对称性异常代谢灶,累及多叶,范围更大。中晚期AD表现无代谢灶或部分无代谢灶,而早期AD显示代谢缺如较少。结论:对CT、MRI未见结构改变而MMSE评分显示认知功能缺损的患者,若^(18)F- FDG SPECT显像以单侧或双侧对称低代谢灶为主的表现,可诊断早期AD,及早行干预治疗。^(18)F-FDG SPECT可作为诊断AD分期的手段。

Objective：To study the image characteristics and diagnosis standard of Alzheimer＇s Disease （AD） with fluorine 18- fluorodeoxyglucose（18F-FDG） single photon emission computed tomography （SPECT）. Methods： All patients were tomographied after injection of 18F-FDG. The image characteristics of frontal lobe, parietal lobe and temporal lobe were analyzed respectively. Results： The MMSE scores was 21 to 26 in 15 patients with early AD, The images show unilateral （especially dominant hemisphere） and bilateral symmetrical abnormal metabolic areas. The MMSE scores was less than 21 in 32 subjects with middle-later periods AD. The images show bilateralsymmetrical abnormal metabolic areas and no-metabolic areas or partial nometabolic areas, the areas involved multy-lobe. The image of early AD seldom shows noetabolic areas. Conclusion： 18F-FDG SPECT is reliable means of the diagnosis and staging standard of AD.