胃癌组织中骨桥蛋白与尿激酶型纤溶酶原激活物的表达

Expression of osteopontin and uPA in gastric carcinoma tissue

目的:探讨胃癌组织中骨桥蛋白(OPN)与尿激酶型纤溶酶原激活剂(uPA)的表达及二者的表达与胃癌侵袭、转移间的关系。方法:应用免疫组织化学方法检测67例进展期胃癌组织、20例癌旁正常组织中OPN与uPA蛋白的表达。结果:67例胃癌组织中OPN与uPA蛋白的阳性表达率分别为70.1%(47/67)、64.2%(43/67)。OPN与uPA的表达与肿瘤组织类型、临床病理分期、浸润深度、淋巴结转移程度及有无远处转移有关(P<0.05),与患者年龄、性别及肿瘤的分化程度无关(P>0.05)。胃癌组织中OPN与uPA蛋白的表达呈正相关(rs=0.669,P<0.05)。结论:OPN、uPA蛋白与胃癌侵袭转移密切相关,能够作为反映肿瘤的生物学特性及评估预后的重要参考指标。

Aim： To investigate the expressions of osteopontin（OPN） and urokinase-type plasminogen activator（uPA） and their relation to the invasiveness and metastasis of gastric carcinoma. Methods：The expression of OPN and uPA in 67 cases of gastric carcinoma tissue and 20 cases of adjacent normal tissue was detected using immunohistochemistry method. Results： In gastric cancer tissue, the positive expression rates of OPN and uPA were 70. 1% （47/67） and 64.2% （43/ 67） ,respectively. The expression of OPN and uPA was related to histological type, pathological stage, invasion depth ,lymphatic and distant metastasis（ P 〈 0.05 ） , but not related to age, sex or differentiation degree（ P 〉 0.05 ）. The expression of OPN was positively correlated with that of uPA in gastric carcinoma tissue （ rs = 0. 669,P 〈 0.05）. Conclusion ： Both OPN and uPA are significantly related to the invasiveness and metastasis of gastric carcinoma. The expression of them can reflect the biological characteristics of gastric carcinoma and could be used as important indicator in prognosis of gastric carcinoma.