上皮性卵巢癌组织中P53和Survivin蛋白的表达

Expression of P53 and Survivin protein in epithelial ovarian cancer tissue

目的:探讨上皮性卵巢癌组织中P53蛋白和Survivin蛋白的表达情况。方法:应用免疫组织化学法检测61例上皮性卵巢癌组织(浆液性腺癌43例,黏液性腺癌18例;高分化30例,中分化21例,低分化10例;伴淋巴结转移30例,无淋巴结转移31例)中P53和Survivin蛋白的表达。结果:61例上皮性卵巢癌组织中P53蛋白阳性表达32例;Survivin蛋白阳性表达40例。P53和Survivin蛋白的表达与上皮性卵巢癌组织学分型无关(P>0.05);与分化程度、临床分期和淋巴结转移有关(P<0.05)。上皮性卵巢癌组织中Survivin蛋白的表达与P53蛋白表达呈正相关(r=0.558,P<0.05)。结论:P53和Survivin蛋白与上皮性卵巢癌组织的发生、发展及转移有关,可作为判断卵巢癌预后不良的指标。

Aim： To investigate the expression of P53 and Survivin protein in epithelial ovarian cancer tissue. Methods：The expression of P53 and Survivin protein in 61 cases of epithelial ovarian cancer （histological types： 43 cases of serous adenocarcinoma, 18 cases of mutinous adenocarcinoma; differentiation degree： 30 cases of high-differentiated, 21 cases of middle-differentiated, 10 cases of low-differentiated; 30 cases with lymph node metastasis, 31 cases, without） tissue was detected using immunohistochemistry. Results： Thirty-two cases had P53 positive expression and 40 cases had Survivin positive expression in 61 cases of epithelial ovarian cancer tissue. The expression of P53 and Survivin was related to differentiation degree, clinical stage, and lymph node metastasis, but not with histological type. The expression of Survivin was correlated with that of P53 （ r = 0. 558, P 〈 0.05 ）. Conclusion ： The expression of P53 and Survivin protein is related to the occurrence, development and metastasis of epithelial ovarian cancer, and can be used as an indicator for judging poor prognosis.