摘要
目的:探讨老年人多种性激素活性变化与认知功能障碍的关系。方法:采用简易智能量表(MMSE)对369例60岁以上入选样本进行认知功能检查,并分为认知功能正常组与认知功能障碍组,每组按性别又分为男、女2个亚组,采用放免法测各组患者血清泌乳素、雌二醇、睾酮、孕酮。结果:同性别认知功能障碍组的泌乳素、雌二醇、睾酮水平较认知功能正常组低。结论:认知功能障碍可能与多种性激素活性下降相关,而非单一因素所致。
Aim: To explore the relationship between the serum sex hormones and cognitive impairment in eider people. Methods :The cognitive function of 369 recruited residents aged ≥ 60 years were tested with Mini Mental State Examination( MMSE). The samples were divided into two groups based on MMSE scores: the normal cognitive group and the impaired cognitive group. The serum sex hormones such as prolactin, estradiol, testosterone, and progesterone were measured with radiolmmunoassay. Results: In the same sex,the levels of serum prolactin,estradiol, and testosterone in the impaired cognitive group were significantly lower than those in the normal cognitive group. Conclusion: The cognitive impairment may be associated with the decline of several sex hormones.
出处
《郑州大学学报(医学版)》
CAS
北大核心
2007年第5期944-946,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
老年人
性激素
认知功能障碍
eider people
sex hormone
cognitive impairment