邻苯二甲醛合成新工艺研究

Study on a new synthetic process of o-phthalaldehyde

邻苯二甲醇在乙酸水溶液中通过硝酸氧化得到目的产物邻苯二甲醛。在单因素实验基础上进行了正交实验,考察醇/酸摩尔比、反应温度、反应时间、醋酸用量等对产品收率的影响。结果表明,优化工艺条件为邻苯二甲醇与硝酸的摩尔比1∶2.5,反应温度80℃,反应时间1 h,收率可达76.0%,含量99.5%。

Synthesis of o-phthalaldehyde from 1,2-benzenedimethanol by the oxidation of nitric acid in the solvent of acetic acid and water. Effect of mole ratio, reaction temperature, time and amount of acetic acid on the yield was investigated. The experimental results showed that the yield of o-phthalaldehyde was about 76.0%, purity was 99.5% under the following conditions： the mole ratio was 1 ： 2.5, at the temperature of 80 ℃ react 1 h.