PTEN、P53与子宫内膜癌发病关系研究

PTEN,P53 and its relationship with endometrial carcinoma

目的研究抑癌基因PTEN、P53在子宫内膜中的表达,探讨其临床意义。方法采用免疫组化法,对正常子宫内膜、子宫内膜增生过长、子宫内膜不典型增生各20例,子宫内膜癌50例及子宫内膜癌旁组织50例中PTEN及P53的表达进行检测。结果PTEN在正常子宫内膜、子宫内膜增生过长、子宫内膜不典型增生、子宫内膜癌旁组织及子宫内膜癌中表达缺失率逐渐上升,P<0.05,差异有显著性。P53蛋白表述在子宫内膜癌中阳性率达44%,P<0.01,差异有极显著性。结论PTEN、P53二者皆为抑癌基因,皆参与子宫内膜癌的发生、发展。

Objective To study the expression and its clinical significance of PTEN and P53 in the pathogensis of endometrial carcinoma methods. Methods A specific and sensitive immnnohistoche mical S-P assay was used to detect the expression of PTEN and P53 in paraffin-embedded sections of 20 cases of normal endometrium, endometrial hyperplasia and atypical hyperplasia of endometrial, 50 the tissue near the endometrial carcinoma and endometrial carcinoma. Results The loss expression rates of PTEN in normal proliferative endometrium, endometrial hyperplasia, atypical hyperplasia of endometrial, the tissue near the endometrial carcinoma, and endometrial carcinoma were gradually increased. The difference was significant. The positive rates of the aberrant expressions of P53 was 44%, and the difference was significant. Condusions PTEN and P53 may play some roles in the carcinogenesis and development of endometrial carcinoma.