乳腺癌患者血清PSA测定的临床意义

Clinical Value of Serum Total and Free PSA in Breast Cancer

目的探讨女性乳腺癌患者血清PSA的水平及其临床意义。方法应用化学发光免疫技术测定正常对照组、良性对照组及乳腺癌患者术前和术后血清总PSA和游离PSA的含量。结果女性乳腺癌患者术前血清PSA的含量明显高于对照组（P〈0．01）。良性对照组与正常对照组比较差异无显著意义（P〉0．05）。术后PSA水平明显下降（P〈0．01）。结论检测女性乳腺肿瘤疾病患者血清PSA的含量，有助于乳腺癌的诊断及治疗观察。

Objective To investigate the serum prostate- specific antigen（PSA） levels and clinical value in patients with breast cancer. Methods The determination of serum total and free PSA in the healthy women, the women with the benign breast tumors, the woman with preoperative and the postoperative of breast cancer with ehemi - luminescence immunoassay system. Results The preoperative serum total and free PSA levels of breast cancer were higher than those of the control group （ P 〈 0.01 ）, While the postoperative serum PSA levels were dropped markedly comparing to that of the preoperative （P 〈0.01 ）. There was no significant difference of PSA between the healthy women and the woman with benign breast tumor （ P 〉 0.05 ）. Conclusion determination of the serum PSA in woman with breast tumor may be helpful to diagnose breast cancer.