甲基强的松龙和地塞米松治疗放射性脑水肿的差异

Comparsion between Curative effects of Methylprednisolone and Dexamethasone on Radiation Cerebral Edema

目的研究甲基强的松龙及地塞米松治疗放射性脑水肿的差异。方法建立大鼠脑胶质瘤模型。实验分组:A组(大剂量甲基强的松龙组)、B组(小剂量甲基强的松龙组)、C组(地塞米松组)、D组(对照组)、E组(空白组)。各组均颅内种植肿瘤,于种植15天后A、B、C、D各组给予Co60照射,A、B、C组大鼠照射前后分别给予甲基强的松龙和地塞米松治疗。测量大鼠脑水肿情况。结果治疗后,与其他各组比较,D组大鼠脑组织含水率最高,E组最低(P<0.05);C组大鼠脑组织含水率明显高于A、B两组(P<0.05);但A、B两组间无显著性差异(P>0.05)。结论甲基强的松龙和地塞米松都可以有效防治放射性脑水肿,且甲基强的松龙比地塞米松疗效更好。

Objective To compare the curative effect of methylprednisolone on radiative cerebral edema with dexamethasone. Methods The intracranial glioma models were established in 100 rats who were divided into groups A （large dose methylprednisolone）, B （small dose methylprednisolone）, C （dexamethasone）, D （control, being irradiated, but not given drugs）, and E （blank, not irradiated and not given drugs）. The brains were irradiated by Co60 15 days after the implantation of glioma cells in groups A, B, C and D. The content of cerebral water was determined. Results The content of cerebral water in group D was significantly higher than that in groups A, B, C and E （P〈O.05）. The content of cerebral water in group C was significantly higher than that in groups A and B （P〈O.05）. There were no significant difference in the content of cerebral water between group A and B （P〉O.05）. Conclusions Methylprednisolone and dexamethasone can effectively decrease radiation cerebral edema, and the curative effect of methylprednisolone on the radiation cerebral edema is better than that of dexamethasone.