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肝细胞生长因子与缺血性脑损伤

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摘要 肝细胞生长因子（hepatocyte growth factor，HGF）是一种多功能细胞因子，它可以作为分裂素、生成素、活力素和细胞毒素作用于各种细胞。内源性肝营养因子的存在早在1949年就被人们发现。但直到将近40年后HGF才从完全分化的肝细胞中被识别、提纯和克隆。HGF的分子序列等同于其他两种单独发现的细胞因子：肿瘤细胞毒因子（tumour cytotoxicfactor）和散射因子（scatter factor）。后者是一种上皮细胞的解离因子。近年来，人们对于HGF在实验及临床应用等各方面的研究都取得了很大进展，现就其在缺血性脑损伤中的作用研究进展综述如下。
作者 柴平锋 杨正明
机构地区 华中科技大学同济医学院附属同济医院神经外科
出处 《中国临床神经外科杂志》 2007年第8期506-507,511,共3页 Chinese Journal of Clinical Neurosurgery
关键词 肝细胞生长因子 结构 分布 受体 生物学作用 缺血性脑损伤
分类号 R743.33 [医药卫生—神经病学与精神病学] Q593.2 [生物学—生物化学]
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参考文献11

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二级参考文献12

  • 1Jung W, Castren E, Odenthal M,et al. Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain[J]. J Cell Biol,1994,126(2):485-494.
  • 2Yamagata T, Muroya K, Mukasa T, et al. Hepatocyte growth factor specifically expressed in microglia activated Ras in the neurons, similar to the action of neurotrophic factors[J]. Biochem Biophys Res Commun,1995,210(1):231-237.
  • 3Tsuzuki N, Miyazawa T, Matsumoto K. Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia in rats[J]. Neurol Res,2001, 23(4):417-424.
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  • 6Nagayama T, Nagayama M, Kohara S, et al. Post-ischemic delayed expression of hepatocyte growth factor and c-Met in mouse brain following focal cerebral ischemia[J]. Brain Res, 2004,999(2):155-166.
  • 7Ma H, Calderon TM, Fallon JT, et al.Hepatocyte growth factor is a survival factor for endothelial cells and is expressed in human atherosclerotic plaques[J]. Atherosclerosis,2002,64(1):79-87.
  • 8Ozaki M, Haga S, Zhang HQ,et al.Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3K and Akt kinase upon rac1[J]. Cell Death Differ, 2003,10(5):508-515.
  • 9Zhang L, Himi T, Morita I, et al. Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinositol 3-kinase/Akt pathway[J]. J Neurosci Res,2000,59(4):489-496.
  • 10Xiao GH, Jeffers M, Bellacosa A, et al. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways[J]. Proc Natl Acad Sci,2001,98(1):247-252.

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中国临床神经外科杂志
2007年 第8期

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