137例结直肠癌FOLFOX4化疗方案患者的护理

Nursing experiences of 137 colorectal carcinoma patients in the treatment of FOLFOX4 chemotherapy

目的探讨应用FOLFOX4化疗方案治疗结直肠癌患者的护理。方法总结2005年11月-2006年6月应用FOXFOL4化疗的137例患者的护理,男102例,女35例,年龄42-77岁,平均63岁;结肠癌95例,直肠癌42例。阐述了化疗方案的治疗方法,药物输注方法,溶液配制方法等。结果137例患者均能耐受FOXFOL4方案,无中途退出治疗者。副作用发生率分别为：恶心、呕吐41.6%,腹泻10.9%,感觉神经毒性12.4%,白细胞下降22.6%,血小板减少19.0%,静脉炎18.2%。结论FOLFOX4治疗方案已作为结直肠癌化疗的一线药物广泛应用。化疗期间出现的副作用一般可经对症处理后缓解,经过宣教,神经感觉毒性反应发生率大大低于多数文献报道。

Objective To discuss the nursing care of colorectal carcinoma patients accepting the treatment of FOLFOX4 chemotherapy. Methods A retrospective analysis was conducted with 137 cases of colorectal carcinoma treated by FOLFOX4 chemotherapy from December of 2005 to June of 2006. There were 102 male cases and 35 female cases, with an average age of 63 （ranging from 42 to 77 ages）, and 95 cases of colon carcinoma and 42 cases of rectal carcinoma, respectively. The treatment of FOL- FOX4 chemotherapy, the method of drug transfusion and the method of solution preparation were discussed. Results All the patients could tolerate with FOLFOX4 chemotherapy. The side-effect incidence rate of vomiting was 41.6%, diarrhea being 10.9%, neurotoxic symptom being 12.4%, leucopenia being 22.6%, thrombocytopenia beingl9.0%, and phlebitis being 18.2%. The neurotoxic symptom was significantly reduced from 93% to 12.4% by healthy propaganda and education. Conclusions FOL- FOX4 chemotherapy has been applied widely as the first-line drug of colorectal carcinoma chemotherapy. The side effects of FOLFOX4 chemotherapy treatment can be reduced by heteropathy. Healthy propaganda and education reduce the incidence rate of neurotoxic symptom significantly, compared with that reported in numerous literatures.