银屑病患者血清中链球菌抗体的研究

The Study of Streptococcal Antigen in Psoriasis

为了进一步证实链球菌感染与银屑病的关系，我们应用免疫印迹法测试了银屑病患者血清中抗链球菌、抗金黄色葡萄球菌及抗白念珠菌抗体含量。发现点滴型银屑病患者的抗链球菌抗体含量不仅显著高于正常人对照组（Ｐ＜０．０１），亦高于慢性斑块型银屑病患者（Ｐ＜０．０５）；但其抗金黄色葡萄球菌、抗白念珠菌抗体含量与对照组相比，结果均无显著性差异（Ｐ＞０．０５）。

The immune response to streptococcus in 40 patients with acute guttate psoriasis (AGP) and 10 patients with chronic plaque psoriasis (CPP) has been studied using immunoblotting technique (IBT). The immune responses to staphylococcus and Candida albicans in patients with AGP were also studied using this technique. Patients with AGP had a significantly higher (P<0 01) anti streptococcal antibody score than that in control group and this score is also higher than that in CPP group (P<0 05); anti streptococcal antibody score of patients with AGP in progressive stage is not significantly higher than that in remission stage (P>0 05). No statistical differences in the anti staphylococcal and anti Candida albicans antibody score were observed between AGP and control group (P>0 05). The immune reponse to streptococcus in patients with AGP using intradermal test of inactivated streptococci was also studied, 26 of 40 patients presented positive results. Our results prove that streptococcal infections are closely correlated with the onset of acute guttate psoriasis.