银屑病患者血浆内皮素含量检测

An Assay of the Levels of Plasma Endothelin in Patients with Psoriasis

为了探讨内皮素与银屑病的关系及其在发病机理中的作用，采用放射免疫分析法检测了３２例正常人及５４例银屑病患者血浆内皮素的变化，其中寻常型银屑病４５例（进行期３２例，静止期１３例），红皮病型银屑病９例。结果显示：正常人血浆内皮素水平为４３．５±１５．７１ｐｇ／ｍｌ，银屑病患者血浆内皮素含量为６２．０１±２１．１５ｐｇ／ｍｌ，较正常对照组显著增高（Ｐ＜０．０１），红皮病型又较寻常型患者的血浆内皮素水平为高（Ｐ＜０．０５）。寻常型银屑病患者中，进行期与静止期相比其内皮素水平虽有增高，但无显著性差异（Ｐ＞０．０５）。本研究提示内皮素可能与银屑病的发病有关，进一步了解其作用机理。

In order to study the relationship between endothelin and psoriasis, we determined the plasma levels of endothelin with the method of radioimmunoassay in 54 patients with psoriasis in comparison with 32 normal subjects. Among the cases of psoriasis, 45 were psoriasis vulgaris (32 in progressive stage and 13 in stable stage) while 9 were erythrodermic psoriasis. The results showed that the level of plasma endothelin in normal controls was 43 5±15 71pg/ml, while the value of psoriatics was 62 01±21 15 pg/ml. The latter was significantly higher than the former (P<0 01). The level of plasma endothelin in erythrodermic psoriasis was higher than that of psoriasis vulgaris(P<0 05). In psoriasis vulgaris, the plasma levels of endothelin between progressive stage and stable stage were not significantly different The above mentioned data suggest that endothelin may have a role in the pathogenesis of psoriasis. It is deemed that further study on the mechanism of action of this substance may be helpful in developing reasonable treatment for psoriasis.