术前盆腔动脉化疗对伴腹水晚期卵巢癌的疗效分析

VALUE OF PREOPERATIVE INTRA ARTERIAL CHEMOTHERAPY FOR ADVANCED OVARIAN CANCER WITH ASCITES

目的评价术前盆腔动脉化疗对伴腹水晚期卵巢癌的疗效。方法Ⅲ期卵巢癌伴腹水４８例在术前接受盆腔动脉化疗１～２疗程（每疗程５天，用药总量ＨＮ２１５ｍｇ，ＣＤ┐ＤＰ１００ｍｇ，ＫＳＭ１４００μｇ或５┐ＦＵ２５００ｍｇ）结果用药后全部病例腹水完全消退，全身情况改善，组织水肿消退。肿瘤缩小或松动，能较彻底切除肿瘤病灶，手术成功率高，术后继续采用化疗、放疗等综合治疗约２年。随访结果为３例存活超过５年，３例超过４年，７例超过３年，９例超过２年。结论对晚期伴腹水的卵巢癌行术前盆腔动脉化疗，手术切除，加术后化、放疗，可得到不同程度的疗效。

Objective:Preoperative intra arterial chemotherapy for advanced ovarian cancer with ascites was evaluated.Methods:One to two courses of chemotherapy were given to 48 patients via inferior epigastric artery (each course 5 days;total dosage:HN 2 15mg,CDDP 100mg, KSM 1400 μg or 5 FU 2500mg). Results: Ascites in all patients disappeared completely,general physical condition improved,and tissue edema reduced. The tumors shrinked, became movable,and could be excised radically. Post operative chemotherapy and/or irradiation should be administered for about 2 years. The follow up showed that 3 cases survived over 5 years, 3 over 4 years,7 over 3 years and 9 over 2 years. Conclusions:Pre operative chemotherapy,surgical operation,plus more chemo and/or radio therapy for the treatment of advanced ovarian cancer with ascites will give a rather satisfactory result.