多沙普仑对犬失血性休克等容输血后血流动力学的影响

Homodynamic effects of doxapram on hemorrhagic shock after isovolumetric blood transfusion

目的：观察多沙普仑对犬失血性休克等容输血后血流动力学的影响。方法：犬分为对照组和多沙普仑组（只数均＝５）。股动脉快速放血３０ｍｌ／ｋｇ，造成严重休克模型，３０分钟后等容输血。多沙普仑组输血后立即静脉注射多沙普仑２ｍｇ／ｋｇ。用Ｓｗａｎ－Ｇａｎｚ漂浮导管等方法分别于休克、输血前后测定血流动力学参数。结果：休克后５分钟、３０分钟ＭＡＰ、ＣＯ、ＣＩ、ＳＶ、ＬＶＳＷ、ＬＶＳＷＩ明显下降，ＳＶＲ明显增高。输血后１５分钟，多沙普仑组已恢复到休克前水平，但对照组则未能恢复。结论：多沙普仑能促进失血性休克等容输血后循环功能的恢复。

Objective:Hemodynamic effects of doxapram on hemorrhagic shock after isovolumetric blood transfusion were studied.Methods:The dogs were divided into doxapram group and control group (5 dogs each group),and were bleeded rapidly form femoral artery at 30ml/kg to induce hemorrhagic shock 30 minutes following shock,isovolumetric blood was transfused into femoral vein In doxaprom group,doxaprom 2mg/kg was given I V immediately after isovolumetric blood transfusion.Hemodynamics were observed before and after shock induction and isovolumetric blood transfusion with Swan Ganz catheter.Results:MAP,CO,CI,SV and LVSWI decreased greatly and SVR increased markedly at 5 and 30 minutes following shock in both groups.All parameters returned to baseline after 15 minutes of isovolumetric blood transfusion in doxapram group,while in contral group hemodynamics were still below the baseline.Conclusions:Doxapram may improve hemodynamic status of hemorrhagic shock after isovolumetric blood transfusion.