牙周基础治疗对冠状动脉粥样硬化性心脏病再发风险影响的研究

Preservative effect of periodontal treatment on recurrence of coronary atherosclerotic heart disease

目的探讨牙周基础治疗对冠状动脉粥样硬化性心脏病(CAD)患者再发风险的影响。方法我院心血管内科诊断为冠心病伴中、重度牙周炎患者42例,通过观察菌斑指数(PI),牙龈指数(GI)和牙周探诊指数(PDI)在牙周基础治疗前后的变化,并检测龈沟液中前列腺素E-2(prostaglandin E2,PGE2)血清高敏C反应蛋白(hsCRP)含量评价牙周基础治疗前后上述指标的差异。结果与对照组比较CAD患者牙周病临床指数、龈沟液中的PGE2及血清中的hsCRP含量均呈现明显差异(P<0.05),实验组与治疗前比较牙周病临床指数差异具有统计学意义(P<0.05)。结论牙周基础治疗对血管内皮损伤相关因子的释放具有抑制作用,对预防冠心病再发具有积极意义。

Objective To investigate the preservative effect of periodontal disease treatment on recurrence of coronary atherosclerotic heart disease （CAD） .Methods Effects of periodontal treatment on forty-two patients with CAD and periodontal disease were investigated through the changes of GI, PI, PDI and prostaglandin E2 （PGE2） of gingival crevicular fluid. Results Compared with control group, obviously statistical differences were found on GI, PI, PDI, PGE2 and hsCRP after the treatment of periodontopathy. Conclusion Periodontal disease treatment can decrease the release of blood vessel endothelium damage correlation factor and can be a positive role in the prevention of recurrence of CAD.