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咪唑安定对体感诱发电位的影响

Influence of midazolam on somatosensory evoked potentials
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摘要 目的:了解咪唑安定对体感诱发电位的影响。方法:选择30例ASAI~Ⅱ级的脑外科手术病人,根据国际10~20系统,在C3或C4、FPz(参考)和SC(第二颈椎棘突处)安放盘状记录电极,记录体感诱发电位。均分为三组按剂量(0.2mg/kg、0.3mg/kg和0.4mg/kg)静脉注射咪唑安定,连续观察皮层N20、P23和颈髓N14电位的变化。结果:(1)用药后,皮层N20和颈髓N14电位的波幅降低,分别抑制到术前的63.75%和48.75%(P<0.05),苏醒后恢复到基础水平;(2)颈髓N14、皮层N20和P23的潜伏期及中枢传导时间均无显著延长,(3)各剂量组间的SEP变化无明显差别。结论:咪唑安定对SEP一定程度的抑制作用临床意义不足,可用作SEP监测时的静脉麻醉药。 Objective:To study effects of midazolam on somatosensory evoked potentials.Methods:We selected 30 ASA grade I to Ⅱ neurosurgical patients undergoing craniotomy All patients were allocated randomly and equally into three groups.Different dosages(0.2mg/kg,0.3mg/kg and 0.4mg/kg)of midazolam were injected intravenously within 2 minutes in three groups respectively Disc recording electrodes were affixed at C3 or C4,SC(the second cervical spinous process)and FPz(as reference)according to international 10 20 system.Cortical(N 20 ,P 23 )and cervical(N 14 )potentials were monitored during whole procedures.Results:Amplitudes of cortical potential N 20 and cervical potential N 14 declined to 63.75% and 48.75% of baselines (P<0.05),but no statistical significances were found among three groups.When consciousness of patients recovered,these amplitudes came to the preoperative values.Latencies of cervical potential N 14 ,cortical potentials N 20 and P 23 ,central conductive time unchanged statistically after the administration.There were no significant changes in SEP among three groups.Conclusion:SEP can be reliable as an intraoperative monitoring method when midazolam is given.
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 1997年第5期259-262,共4页 Chinese Journal of Anesthesiology
关键词 诱发电位 体感 咪唑安定 监测 Evoked potentials,somatosensory Midazolam Monitoring
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