摘要
采用体外温孵系统，观察麝香糖蛋白成分麝香－１对大鼠中性白细胞花生四烯酸代谢酶，包括磷脂酶Ａ２、５－脂氧酶和环氧酶活性的影响。结果表明：终浓度为１～１００μｇ／ｍｌ的麝香－１使ＡＡ释放量增加６．０％～２１．６％，使ＬＴＢ４生成量减少９％～８１％，使６－酮－ＰＧＦ１α生成量增加１８．２％～８５．４％。
To investigate the effects of musk 1, a glucoprotein component isolated from the water extract of musk, on arachidonic acid metabolizing enzymes,which include phospholipase A 2 (PLA 2), 5 lipoxygenase (5 LO), and cyclooxygenase (COX), in rat polymorphonuclear leukocytes, an in vitro incubation system with rat polymorphonuclear leukocytes or homogenate supernatant of the same cells was used. In comparison with control, musk 1 at final concentrations of 1～100μg/ml can increase AA release from PMNL by 6.0%～21.6%,decrease LTB 4 biosynthesis in homogenate supernatant of the cells by 9%～81%, but increase 6 keto PGF 1α production by 18.2%～85.4%.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1997年第5期301-303,共3页
China Journal of Chinese Materia Medica
基金
国家自然科学基金
关键词
麝香
中性白细胞
5-脂氧酶
环氧酶
musk
polymorphonuclear leukocyte
phospholipaseA 2
5 lipoxygenase
cyclooxygenase
