活(破)血逐瘀法治疗真性红细胞增多症疗效观察及其机理探讨

Activating Blood Circulation and Removing Stasis in Treating Polycythemia Vera: Clinical Observation and Therapeutical Mechanism

目的：为寻找治疗真性红细胞增多症（ｐｏｌｙｃｙｔｈｅｍｉａｖｅｒａ，ＰＶ）的有效方法。方法：应用活（破）血逐瘀法治疗２８例ＰＶ患者。结果：其中４例临床缓解，１１例好转，总有效率达５３．６％。活（破）血逐瘀法治疗有效者骨髓中红细胞生成素依赖性红系祖细胞（ＥＰＯ＋ＣＦＵ－Ｅ）及红细胞生成素非依赖性红系祖细胞（ＥＰＯ－ＣＦＵ－Ｅ）均明显减少，尤以后者更为显著。结论：本疗法主要通过作用于ＥＰＯ－ＣＦＵ－Ｅ而发挥疗效；此外，活（破）血逐瘀治疗有效者骨髓成纤维样祖细胞（ＣＦＵ－Ｆ）数量亦有明显变化。

To assess the efficacy of 'method of activationg blood circulation and removing stasis (ABCRS)' in treating polycythemia vera. Methods: 28 cases of polycythemia vera were treated with ABCRS and observed with bone marrow colonies. Results: 15 oasses were responsibe, of them 4 cases reached clinical remission, 11 cases were improved. Both bone marrow colonies of colony forming unit-erythroid dependent of erythropoietin (EPO+CFU-E)and colonies of CFU-E independent of EPO (EPO-CFU-E) from these cases decreased significantly especially the latter. ABCRS mainly suppressed the proliferation and differentiation of EPO-CFU-E. In addition, bone marrow colonies of colony formng unit-fibroblastoids (CFU-F) from these cases also changed obviously. Conclusion: ABCRS iseffective in treating polycythemia vera.