代谢综合征病人C反应蛋白与心血管病危险因素关系

Correlation between risk factors of cardiovascular diseases and C-reaction protein in patients with metabolic syndrome

目的了解代谢综合征病人C反应蛋白与心血管病危险因素之间的关系。方法回顾分析代谢综合征175例,根据C反应蛋白水平分为高C反应蛋白组和正常C反应蛋白组。检测两组体质量指数、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇、甘油三酯、空腹血糖、餐后2小时血糖、糖化血红蛋白、收缩压和舒张压。结果高C反应蛋白组的体质量指数、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、空腹血糖、餐后2小时血糖、糖化血红蛋白、收缩压、舒张压均显著高于正常C反应蛋白组,而高密度脂蛋白胆固醇水平显著低于后者(P<0.01);C反应蛋白水平与体质量指数、甘油三酯、低密度脂蛋白胆固醇、糖化血红蛋白、舒张压、空腹血糖及餐后2小时血糖水平呈正相关(P<0.05),与高密度脂蛋白胆固醇呈负相关(P<0.05)。结论代谢综合征病人中C反应蛋白升高者往往伴随多种代谢紊乱加重,心血管病的危险因素亦随之加重,故对此类病人更要加强防治措施。

Objectives To investigate the correlation between risk factors of cardiovascular diseases and serum high sensitivity C-reactive protein （CRP） in patients with metabolic syndrome （MS）. Methods According to their CRP level, 175 patients with MS were divided into high CRP level group and normal CRP level group. BMI, TC, TG, FPG, 2HPG, GHbA1, HDL-C, LDL-C, SBP, DBP were determined in all individuals. Results HS-CRP patients had significantly higher levels in BMI, TC, TG, FPG, 2HPG, GHbA1, LDL-C, SBP, DBP than normal CRP patients. But HDL-C was lower then latter. Correlation analysis showed that CRP levels was positively correlated with BMI, TC, TG, FPG, 2HPG, GHbA1, LDL-C, SBP, DBP and reverse correlated with HDL-C. Conclusions Increased CRP levels may lead to worsened metabolic disturbances and increased cardiovascular risks.