HBV携带者肺结核化疗的肝脏预防性保护探讨——附40例临床分析

The prophylactic protection of HBV carrier's livers for pulmonary tuberculosis' patients (40 case's reports)

目的探讨多烯磷脂酰胆碱联合硫普罗宁对乙肝病毒(HBV)携带者肺结核化疗的肝脏预防性保护作用。方法将78例HBV携带的肺结核患者随机分为两组,抗痨过程中对照组常规用肌苷片?肝泰乐治疗,治疗组在对照组基础上加用多烯磷脂酰胆碱?硫普罗宁。两组在化疗过程中或结束后对比肝功能损害发生的时间?类型及损害程度。结果治疗组较对照组出现肝损害的发生率明显减少,程度轻。未受到预防性肝脏保护的对照组出现肝损害的时间也较早,以肝细胞损害为主,病情严重。提示两组在抗结核化疗中肝损害差异有显著性意义(P<0.05)。结论多烯磷脂酰胆碱联合硫普罗宁对HBV携带肺结核患者化疗对肝脏功能有预防性保护作用。

Destination To discuss the value of prophylactic protection to HBV carrier＇ s livers for pulmonary tuberculosis＇ patients with polyene phosphatidylcholine and tiopronin. Method All 78 cases were divided into objective group and control group. Control group were treated with inosine and glucurolactone and objective group were treated with polyene phosphatidylcholine and tiopronin except inosine and glucurolactone. The time, type and level of hepatic function＇ s damages were observed after treatments. Results The rate, time and level of objective group＇ s hepatic function damages were lower, later and lighter to the control group＇ s. The difference was significant between them （ P 〈 0. 05 ）. Conclusion It＇ s a good way to protect hepatic function of pulmonary tuberculosis＇ patients carried HBV with polyene phosphatidylcholine and tiopronin after treating with anti-pulmonary tuberculosis＇ drug.