角层下脓疱性皮肤病的研究进展

Advances in subcorneal pustular dermatosis

角层下脓疱性皮肤病的病因与发病机制尚不完全清楚,可能是一种自身免疫性疾病,也可能是脓疱性银屑病的一种亚型,发病与多种炎症因子相关。病理特征为角层下脓疱内中性粒细胞浸润。鉴别诊断包括:脓疱疮、落叶性天疱疮、疱疹样皮炎、脓疱性银屑病、急性泛发性发疹性脓疱病和IgA天疱疮等。氨苯砜是治疗角层下脓疱性皮肤病的一线用药,英利昔单抗和咪唑立宾是有希望的有效治疗药物,但仍需更多的临床试验来证实。

The etiology and pathogenesis of subcomeal pustular dermatosis remain unknown. It may be an autoimmune disease or a subtype of pustular psoriasis, caused by multiple inflammatory factors. Histopathologically, subcomeal pustules with neutrophilic infiltration are the hallmark sign of the disease. It should bc differentiated from impetigo, pemphigus foliaceus, dermatitis herpetiformis, pustular psoriasis, acute generalized exanthematous pustulosis and IgA pemphigus, et al. Dapsone is the recommended treatment of this disease, lnfliximab and mizoribine are promising to be effective for it, but more clinical trials are still needed.