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Th1胞特异性表面分子TIM-3研究进展 被引量：1

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摘要 CD4^＋Th细胞活化后根据其分泌的细胞因子和效应功能的不同被区分为Th1和Th2型，Th1细胞分泌白细胞介素（IL）-2、干扰素（IFN）-γ和肿瘤坏死因子（TNF）-α等，介导针对细胞内病原体如细菌、病毒感染引起的细胞免疫，与迟发型超敏反应（DTH）和自身免疫病如系统性红斑狼疮（SLE）、类风湿关节炎（RA）、多发性硬化症（MS）、胰岛素依赖型糖尿病（IDDM）等有关；
作者 张胜桃 吴蕊 李昌林 何培根
机构地区 华中科技大学同济医学院附属同济医院风湿科
出处 《中华风湿病学杂志》 CAS CSCD 2007年第9期564-566,共3页 Chinese Journal of Rheumatology
基金 国家自然科学基金资助项日（30671955） 教育部留学回国人员科研启动基金资助项目（教外司留[2005]546号） 中国博士后科学基金资助项目（2005038540）.
关键词 TH1 TIM-3 表面分子 干扰素(IFN)-Γ 胰岛素依赖型糖尿病 CD4^+Th (TNF)-Α 系统性红斑狼疮
分类号 R686 [医药卫生—骨科学]
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参考文献18

  • 1Lack G, Renz H, Saloga J, et al. Nebulized but not parenteral IFN-g decreases IgE production and normalizes airways function in a murine modet of allergen sensitization. J Immunol, 1994, 152: 2546-2554.
  • 2Nieholson LB, Greer JM, Sobel RA, et al. An ahered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity, 1995, 3: 397-405.
  • 3Akira, S. Functional roles of STAT family proteins: lessons from knockout mice. Stem Ceils, 1999, 17: 138-146.
  • 4Mullen AC, High FA, Hutchins AS, et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science, 2001, 292: 1907-1910.
  • 5Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4^+ T ceils. Cell, 1997, 89: 587-596.
  • 6Bonecchi R, Bianchi G, Bordignon PP, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper ceils (THIs) and TH2s. J Exp Med, 1998, 187: 129-134.
  • 7Kuchroo VK, Umetsu DT, DeKruyff RH, et al. The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol, 2003, 3: 454-462.
  • 8Monney L, Sabatos CA, Gaglia JL, et al. Thl-speciflc cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature, 2002, 415: 536-541.
  • 9Han WK, Bailly V, Abichandani R, et al. Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int, 2002, 62: 237-244.
  • 10Mclntire JJ, Umetsu SE, Akbari O, et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nature Immunol, 2001, 2:1109-1116.

二级参考文献15

  • 1Gregersen PK.Genetics of rheumatoid arthritis:confronting complexity.Arthritis Res,1999,1:37-44.
  • 2Edwards JC,Cambridge G.Rheumatoid arthritis:the predictable effect of small immune complexes in which antibody is also antigen.Br J Rheumatol,1998,37:126-130.
  • 3Cush JJ,Lipsky PE.Phenotypic analysis of synovial tissue andperipheral blood lymphocytes isolated from patients with rheumatoid arthritis.Arthritis Rheum,1998,31:1230-1238.
  • 4Park SH,Min DJ,Cho ML,et al.Shift toward T helper 1 cytokines by type Ⅱ collagen-reactive T cells in patients with rheumatoid arthritis.Arthritis Rheum,2001,44:561-569.
  • 5Monney L,Sabatos CA,Gaglia JL,et al.TM-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.Nature,2002,415:536-541.
  • 6Lack G,Renz H,Saloga J,et al.Nebulized but not parenteral IFN-g decreases IgE production and normalizes airways function in a murine modle of allergen sensitization.J Immunol,1994,152:2546-2554.
  • 7Nicholson LB,Greer JM,Sobel RA,et al.An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis.Immunity,1995,3:397-405.
  • 8Sabatos CA,Chakravarti S,Cha E,et al.TIM-3/TIM-3-ligand interaction regulates Th1 responses and induction of peripheral tolerance.Nat Immunol,2003,4:1102-1110.
  • 9Khademi M,Illes Z,Gielen AW,et al.T cell Ig-and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in multiple sclerosis.J Immunol,2004,172:7169-7176.
  • 10Chae SC,Park YR,Shim SC,et al.The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.Immunology Letter,2004,95:91-95.

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中华风湿病学杂志
2007年 第9期

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