雾化吸入沙丁胺醇合并布地奈德治疗毛细支气管炎疗效观察

Clinical Investigation on Effect of Salbutamol and Budesonide by Nebuliztion in the Treatment of Bronchiolitis

目的观察雾化吸入沙丁胺醇合并布地奈德治疗毛细支气管炎疗效。方法我科2004年1月～2006年1月门诊诊断为毛细支气管炎的患儿共60例，随机分为两组，治疗组30例，对照组30例，观察临床疗效。结果治疗组治愈率为93．3％，有效率为100％；对照组治愈率为53．3％，有效率为86．6％，经统计学分析两者差异有显著性（P〈0．05）。治疗组喘憋症状缓解、喘鸣音消失时间均较对照组短（P〈0．01）。结论雾化吸入沙丁胺醇合并布地奈德治疗毛细支气管炎使用方便安全，疗效确切，不良反应小。

Objective To observe the clinical effect of salbutamol and budesonide by nebulization in treatment of bronchiolitis. Methods From Jan 2004 to Jan 2006, 60 cases of patients with bronchiolitis were divided into control group （30 cases） and therapeutic group （30 cases） ; and clinical effect was observed. Results Cure rate and effect rate in therapeutic group were 93.3% and 100% respectively, but in control group they were 53.3% and 86.6% respectively. There was significant difference between two groups（P 〈 0. 05 ）. The time course of symptom relief and wheezing extinction in therapeutic group was shorter than that of control group （P 〈 0. 01 ）. Conclusions Salbutamol combined with budesonide by nebulization in the treatment of bronchiolitis is convenient and safe, and the effect is certain with little side effect.