尿路感染病原菌的分布及耐药性分析

Analysis of the Pathogenic Bacterium Distribution and Antibiotic Resistance of Urinary Tract Infection

目的分析尿路感染病原菌的分布及耐药情况，指导临床合理使用抗菌药物。方法收集2004年5月～2006年12月，住院及门诊尿路感染患者的清洁中段尿培养阳性的病原菌进行鉴定和耐药分析。结果尿路感染共分离病原菌398株，革兰阴性杆菌290株占72．9％，革兰阳性菌63株占15．8％，真菌45株占11．3％；主要的病原菌依次为大肠杆菌（197株）、真菌（45株）、肠球菌属（35株）。药敏结果提示大多数细菌对各种抗菌药物出现多重耐药，革兰阴性杆菌对亚胺培南敏感，革兰阳性球菌对万古霉素敏感。结论定期系统地进行细菌感染的分布及耐药性监测，对指导临床合理应用抗菌药物具有重要意义。

Objective To analyze the pathogenic bacterium distribution and antibiotic resistance of the urinary tract infection, and provide scientific basis for clinical rational using of antibiotics. Methods Collected the samples of clean catch midstream urine of the residents and the out - patients from may. 2004 to dec. 2006, and analyzed about the identifying and antibiotic resistance of the positive urine culture. Results There were 398 strains pathogenic bacterial in urinary tract infection, the most common were Gram - negative bacterial 290 strains （ 72.9% ）, followed by Gram - positive cocci 63 strains （ 15.8 % ） and the next were Fungi 45 strains （ 11. 3 % ）, among which the most pathogenic bacterial were Escherichia coli （ 197 strains）, Fungi （45strains）. Enterococcus （35strains） o And the most bacterial showed multi - drug resistance, The Gram - negative bacterial were sensitive to imipenem and the Gram - positive cocci were sensitive to vancomycin. Conclutions It＇s very important for providing the clinical use of antibiotic more resonable to analyze the bacteria distribution and antibiotic resistance.