比索洛尔联合缬沙坦逆转高血压左心室肥厚的临床观察

Clinical observation on the effect of bisoprolol combined with benalapril on left ventricular hypertrophy due to hypertension

目的已有研究表明血管紧张素转换酶抑制剂(ACEI)和β-受体阻滞剂联用均可逆转左心室肥厚(LVH),观察比索洛尔和缬沙坦联合应用逆转原发性高血压(EH)伴左室肥厚的临床效果,与用比索洛尔联合贝那普利比较,效果无差异。方法将84例原发性高血压伴左室肥厚的患者随机分为比索洛尔加贝那普利组(A组)46例和比索洛尔加缬沙坦组(B组)38例,比较两组治疗前后左室舒张末内径(LVDd)、舒张期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室射血分数(LVEF)、心排出量(CO)、A峰/E峰比值(AE比值)、左室重量指数(LVMI)。结果A组、B组治疗前后LVEF、CO、LVDd无变化(P>0.05);AE比值、LVMI、IVST、LVPWT两组均明显下降(P均<0.01),两组之间比较无差异(P>0.05)。结论比索洛尔和缬沙坦联合应用与和贝那普利联用一样能显著逆转原发性高血压伴左室肥厚,改善预后。

Objective To observe the effect of bisprolol combined with valsartan on left centricular hypertrophy（LVH） patients associated with essential hypertension （EH）. Methods There 84 LVH patients associated with EH were randomly divided into two group A and B. The 46 Patients in group A were treated with blsprolol combined with benalapril and the 38 patients in group B were treated with bisoprolol combined with valsartan. Before and after treatment ,the changes of left ventrlcular diastolic diameter（LVDd）, interventricular septal thick（IVST）,left ventricular posterior wall thick （LVPWT）, left ventricular ejection fraction（ LVEF）, cardiac output（CO） ,the ratio of E peak：A peak（E：A ratio） and left ventricular mass index（LVMI）were observed. Results Before and after treatment the levels of LVEF, CO and LVDD in both groups were almost the same （ P 〉 0.05 ） ; A ： E ratio, LVMI, IVST and LVPWT all decreased significantly （P 〈 0, 05 ） and there no significant differences were observed between the two groups. Conclusion Bisoprolol combined with valsartan can significantly improve LVH in patients with EH.